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Ragweed allergy food cross reactivity5/18/2023 ![]() We conclude that a novel cross-reactive allergen between aeroallergens and foods has been identified. ![]() This study demonstrates the existence of a new allergen responsible for cross reactivity between moulds and two frequently consumed foods, mushroom and spinach. The immunoblotts performed showed that seven moulds allergic patients had a strong recognition of a protein with a molecular weight of about 30 kD present both in spinach and mushroom extracts, and by means of inhibition assays we could determine that these two proteins were related. Statistical analysis of data showed a relation between allergenicity to moulds (Alternaria alternata, Cladosporium herbarum and/or Aspergillus fumigatus), and positive skin prick tests with mushroom and/or spinach. 23 Patients may be more symptomatic during ragweed season when consuming cantaloupe, adding to their critical allergic load. Other associations described have included ragweed and some melons or bananas for example. Inhibition experiments have been also performed to study a possible relation between proteins. Foods may cross-react with inhalants as in the oral allergy syndrome described later. Pollen food allergy syndrome (PFAS) is caused by cross-reactivity with pollen antigens and is classified as a Class 2 food allergy 13.The major allergens of PFAS are Bet v 1 homologs, also known as pathogenesis-related protein type 10 (PR-10), and profilin proteins. To the in vitro assays, mushroom and spinach extracts have been obtained, and sera from moulds allergic patients analysed by means of IgE-immunoblott assays. Data from in vivo tests performed with spinach and mushroom have been statistically analysed. We have performed a dual study in vivo and in vitro, in a population of atopic patients. The major allergens of PFAS are Bet v 1 homologs, also known as pathogenesis-related protein type 10 (PR-10), and profilin proteins 4. The present investigation is undertaken to demonstrate a novel cross-reactivity between aeroallergens (moulds fungi imperfecti) and allergens from foods (spinach and mushroom Agaricus bisporus). Pollen food allergy syndrome (PFAS) is caused by cross-reactivity with pollen antigens and is classified as a Class 2 food allergy 13.
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